Lemon Bottle

No. A PubMed search for the trade name returns zero indexed results. The references on this page are all studies of the individual components — phosphatidylcholine, bromelain and riboflavin — and the specific three-part combination has not been evaluated in the peer-reviewed literature.

Principally by omitting sodium deoxycholate. Classical injection-lipolysis solutions combined phosphatidylcholine with deoxycholate, and much of the published clinical experience is with that pairing. Since deoxycholate is itself a cell-lysing detergent, removing it is a substantive formulation change rather than a minor one — and it means the older clinical literature does not transfer cleanly.

No, and they are worth keeping apart. Deoxycholic acid is a single bile-salt molecule and is the active in the one injectable fat-reduction drug the FDA has approved, for submental fat specifically. This is a three-ingredient solution that contains no deoxycholic acid at all.

Riboflavin is the precursor to FAD, the cofactor mitochondrial acyl-CoA dehydrogenases need to run fatty-acid beta-oxidation, and it is also what gives the solution its yellow colour. The biochemistry is solid; what has not been shown is that adding riboflavin locally changes the rate of that pathway in tissue that already has enough of it.

Cold, dark, and never frozen. It ships as a solution, so there is nothing to reconstitute. Keep it at 2–8 °C in its carton because the riboflavin is light-sensitive, avoid freeze-thaw cycles which can precipitate the phospholipid, and discard the vial if the solution goes cloudy or separates.