For research & educational purposes only. This article is a neutral, procedural reference for laboratory / in-vitro research handling — not medical advice or a usage recommendation. These materials are not for human or animal consumption.
What CJC-1295 (No DAC) is
CJC-1295 in its no-DAC form (also called modified GRF 1-29) is a lab-made analog of growth-hormone-releasing hormone, GHRH. It is supplied as an analytical-grade reference material for laboratory research.
What it does — in plain terms
Your brain sends GHRH to the pituitary gland as a 'please make some growth hormone' message. CJC-1295 copies that message, but small structural tweaks make it more stable, so it lasts longer than natural GHRH. In research it's used to study how stimulating the GHRH receptor changes the release of growth hormone and its downstream messenger IGF-1 — and, notably, the studies found the pituitary keeps firing in its natural pulses rather than one flat surge. The no-DAC version is shorter-acting than the albumin-binding 'DAC' version, so labs pick one or the other depending on the experiment.
Here's where CJC-1295 (No DAC) actually shows up in the published research:
- How the GHRH receptor stimulates growth-hormone release
- Growth hormone and IGF-1 secretion
- Pulsatile versus continuous pituitary signaling
- Endocrine research
Plain-language explanations describe what researchers study — not what any product does for a person, and not medical advice. Every material here is sold for laboratory research use only and is not for human or animal use.
Reconstitution reference
Standard laboratory reconstitution volumes for CJC-1295 (No DAC), from the VNG Reconstitution Sheet. See the full reconstitution guide for the method and concentration math.
| Product | Vial | Bacteriostatic water | Resulting concentration |
|---|---|---|---|
| CJC-1295 + Ipamorelin | 5 mg + 5 mg | 2 mL | 5 mg/mL (of the blend) |
Published research
A selection of peer-reviewed and clinical literature indexed on PubMed. Provided so qualified researchers can locate the primary sources — inclusion here is not a claim about any product or outcome.
- Human studyThe Journal of clinical endocrinology and metabolism · 2006
Prolonged stimulation of growth hormone and IGF-I secretion by CJC-1295, a long-acting GHRH analog, in healthy adults
View on PubMed - Human studyThe Journal of clinical endocrinology and metabolism · 2006
Pulsatile secretion of growth hormone persists during continuous stimulation by CJC-1295
View on PubMed - Animal studyAmerican journal of physiology. Endocrinology and metabolism · 2006
Once-daily CJC-1295, a long-acting GHRH analog, normalizes growth in the GHRH-knockout mouse
View on PubMed - Lab studyEndocrinology · 2005
hGRF(1-29)-albumin bioconjugates activate the GRF receptor: identification of CJC-1295 as a long-lasting analog
View on PubMed
References & resources
Related reference materials
VNG Research Team
VNG Labs supplies analytical-grade reference materials with lot-matched Certificates of Analysis. Our write-ups are neutral, source-cited references for qualified and independent researchers.
More from LearnResearch use only. Not for human consumption or veterinary use. Sold exclusively to qualified researchers for in vitro and laboratory research. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Refrigerate upon receipt. Keep in dark environment.